Publications

2022

PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer.

Duk Ki Kim, Juhee Jeong, Dong Sun Lee, Do Young Hyeon, Geon Woo Park, Suwan Jeon, Kyung Bun Lee, Jin-Young Jang, Daehee Hwang, Ho Min Kim & Keehoon Jung.

Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex.

Hyojin Kim, Yaoyao Fu, Ho Jeong Hong, Seong-Gyu Lee, Dong Sun Lee & Ho Min Kim.

A dynamic substrate pool revealed by cryo-EM of a lipid-preserved respiratory supercomplex. Antioxid Redox Signal.

Tae Jin Jeon, Seong-Gyu Lee, Suk Hyun Yoo, Myeongbin Kim, Dabin Song, Joong Hyun Ryu, Hwangseo Park, Deok Soo Kim, Jaekyung Hyun, Ho Min Kim, Seong Eon Ryu.

Latrophilin-2 is a novel receptor for LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function.

Yin GN, Kim D-K, Kang JI, Im Y, Lee DS, Han A-R, Ock J, Choi M-J, Kwon M-H, Limanjaya A, Jung S-B, Yang J, Min KW, Yun J, Koh Y, Park J-E, Hwang D, Suh J-K*, Ryu J-K*, Kim HM*.

2021

Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody.

Gyunghee Jo, Jeomil Bae, Ho Jeong Hong, Ah-Reum Han, Do-Kyun Kim, Seon Pyo Hong, Jung A Kim, Sangkyu Lee, Gou Young Koh, Ho Min Kim.

High-yield synthesis and purification of recombinant human GABA transaminase for high-throughput screening assays.

Mingu Gordon Park, Ah-Reum Han, Su Yeon Kim, Tai Young Kim, Ho Min Kim, C Justin Lee.

Uncovering the Conformational Distribution of a Small Protein with Nanoparticle-Aided Cryo-Electron Microscopy Sampling.

Hosung Ki, Junbeom Jo, Youngmin Kim, Tae Wu Kim, Changin Kim, Yeeun Kim, Chang Woo Kim, Srinivasan Muniyappan, Sang Jin Lee, Yonggwan Kim, Ho Min Kim, Yongsoo Yang, Young Min Rhee, and Hyotcherl Ihee.

Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2.

Dongjin Jeong, Hye Sung Kim, Hye Young Kim, Min Jueng Kang, Hyeryeon Jung, Yumi Oh, Donghyun Kim, Jaemoon Koh, Sung-Yup Cho, Yoon Kyung Jeon, Eun Bong Lee, Seung Hyo Lee, Eui-Cheol Shin, Ho Min Kim, Eugene C Yi, Doo Hyun Chung.

Nasal ciliated cells are primary targets for SARS-CoV-2 replication in early stage of COVID-19.

Ji Hoon Ahn, JungMo Kim, Seon Pyo Hong, Sung Yong Choi, Myung Jin Yang, Young Seok Ju, Young Tae Kim, Ho Min Kim, MD Tazikur Rahman, Man Ki Chung, Sang Duk Hong, Hosung Bae, Chang-Seop Lee, and Gou Young Koh.

Mastocytosis-derived extracellular vesicles deliver miR-23a and miR-30a into pre-osteoblasts and prevent osteoblastogenesis and bone formation.

Do-Kyun Kim, Geethani Bandara, Young-Eun Cho, Hirsh D Komarow, Danielle R Donahue, Baktiar Karim, Moon-Chang Baek, Ho Min Kim, Dean D Metcalfe, Ana Olivera.

Development of an Antibody-Like T-cell Engager based on VH-VL heterodimer formation and its application in cancer therapy.

Seil Jang, Jaeho Song, NaYoung Kim, Jeonghyeon Bak, Keehoon Jung, Young Woo Park, Bum-Chan Park, Ho Min Kim.

2020

Multivalent-Interaction-Driven Assembly of Discrete, Flexible, and Asymmetric Supramolecular Protein Nano-Prisms.

Suyeong Han, Yu-na Kim, Gyunghee Jo, Young Eun Kim, Ho Min Kim, Jeong-Mo Choi, Yongwon Jung.

Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2.

Jeonghwan Youk, Taewoo Kim, Kelly V. Evans, Young-Il Jeong, Yongsuk Hur, Seon Pyo Hong, Je Hyoung Kim, Kijong Yi, Su Yeon Kim, Kwon Joong Na, Thomas Bleazard, Ho Min Kim, Mick Fellows, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Seon Young Kim, Young Tae Kim, Gou Young Koh, Byeong-Sun Choi, Young Seok Ju, Joo-Hyeon Lee.

Metal-mediated protein oligomerization using a genetically incorporated metal-chelation amino acid.

Sanggil Kim, Jeongwon Yun, Hyunjung Yoo, Sooin Kim, Ho Min Kim, and Hyun Soo Lee.

Preclinical Efficacy and Safety of VEGF-Grab, A Novel anti-VEGF drug, and Its Comparison to Aflibercept.

Hye Kyoung Hong; Young Joo Park; Duk Ki Kim; Na-Kyung Ryoo; You-Jin Ko; Kyu Hyung Park; Ho Min Kim; Se Joon Woo.

Human leucine-rich-alpha-2-glycoprotein1: purification, crystallization, and X-ray crystallographic analysis.

Beom Seok Park, Seoung Youn Won, Dong Sun Lee and Ho Min Kim.

ClpL is a functionally active tetradecameric AAA+ chaperone, distinct from hexameric/dodecameric ones.

Gyuhee Kim, Seong-Gyu Lee, Seungsu Han, Jaeeun Jung, Hyeong Seop Jeong, Jae-kyung Hyun, Dong-Kwon Rhee, Ho Min Kim, Sangho Lee.

Neural Circuit Analysis Using a Novel Intersectional Split Intein-Mediated split-Cre Recombinase System.

Audrey Tze Ting Khoo, Paul Jong Kim, Ho Min Kim, H. Shawn Je.

Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex.

Eunyoung Jeong, Seong-Gyu Lee, Hyun-Suk Kim, Jihyeon Yang, Jinwoo Shin, Youngran Kim, Jihan Kim, Orlando D Schärer, Youngjin Kim, Jung-Eun Yeo, Ho Min Kim, Yunje Cho.

Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency.

Jae-Hee Chung, Seon-Hui Hong, Nari Seo, Tae-Shin Kim, Hyun Joo An, Pedro Lee, Eui-Cheol Shin, Ho Min Kim.

2019

Fabrication of rigidity and space variable protein oligomers with two peptide linkers.

Hyeokjune Choi, Hyoin Park, Kabi Son, Ho Min Kim, Yongwon Jung.

Pro-angiogenic Ginsenosides F1 and Rh1 inhibit Vascular Leakage by Modulating NR4A1.

Ji In Kang, Yoonjung Choi, Chang-Hau Cui, Daeyoup Lee, Sun Chang Kim, Ho Min Kim.

Synaptic organizer: Slitrks and type IIa receptor protein tyrosine phosphatases.

Seoung YounWon, PedroLee, Ho MinKim.

Major Publications

Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release.

Byungjun Ahn, Seong-Gyu Lee, Hye Ryeon Yoon, Jeong Min Lee, Hyeok Jin Oh, Ho Min Kim, Yongwon Jung.

Multi-paratopic VEGF decoy receptor have superior anti-tumor effects through anti-EGFRs and targeted anti-angiogenic activities.

Dae Hee Lee, Myeong Youl Lee, Youngsuk Seo, Hyo Jeong Hong, Hyun Joo An, Jong Soon Kang, Ho Min Kim.

Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14 and TLR4-MD2 for efficient LPS recognition and transfer.

Je-Kyung Ryu, Soo Jin Kim, Sang-Hyun Rah, Ji In Kang, Hi Eun Jung, Dongsun Lee, Heung Kyu Lee, Jie-Oh Lee, Beom Seok Park, Tae-Young Yoon, Ho Min Kim.

Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion.

Ji Won Um, Kee Hun Kim, Beom Seok Park, Yeonsoo Choi, Doyoun Kim, Cha Yeon Kim, Soo Jin Kim, Minhye Kim, Ji Seung Ko, Seong-Gyu Lee, Gayoung Choii, Jungyong Nam, Won Do Heo, Eunjoon Kim, Jie-Oh Lee, Jaewon Ko, Ho Min Kim.

Reconfiguration of the proteasome during chaperone-mediated assembly.

Soyeon Park, Xueming Li, Ho Min Kim, Chingakham Ranjit Singh, Geng Tian, Martin A. Hoyt, Scott Lovell, Kevin P. Battaile, Michal Zolkiewski, Philip Coffino, Jeroen Roelofs, Yifan Cheng, Daniel Finley.

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.

Ho Min Kim, Beom Seok Park, Jung-In Kim, Sung Eun Kim, Judong Lee, Se Cheol Oh, Purevjav Enkhbayar, Norio Matsushima, Hayyoung Lee, Ook Joon Yoo, Jie-Oh Lee.