Chief Investigator

Ho Min Kim, Ph.D.

Dr. Ho Min Kim joined the Graduate School of Medical science & Engineering (GSMSE), KAIST in 2011 and established the “Disease Molecule Biochemistry Lab”. Using structural biology techniques (X-ray Crystallography and Cryo-EM) as well as biochemical and cell-biological approaches, he has been investigated the molecular mechanisms of various protein complexes which play a critical role in human pathophysiology such as immune response and synaptogenesis. In parallel, based on the structure of disease-related protein complexes, he designed new therapeutic hybrid proteins and further develop them as potential biologics for cancer treatment.

In December, 2018, he has appointed as a chief investigator and launched the Protein Communication group (Center for biomolecular and cellular structure) at IBS Headquarter.

Educations

  • 1995-1999 B.S., KAIST, Department of Biological Science

  • 1999-2001 M.S., KAIST, Department of Biological Science

  • 2001-2005 Ph.D., KAIST, Department of Biological Science


Research and Professional Careers

  • 2005-2006 Postdoctoral Fellow (Prof. Ook Joon, Yoo) Biomedical Research Center, KAIST

  • 2006-2007 Postdoctoral Fellow (Prof. Jie-oh, Lee), Department of Chemistry, KAIST

  • 2007-2011 Postdoctoral Fellow (Prof. Yifan, Cheng), Department of Biophysics and Biochemistry, University of California San Francisco

  • 2011-2015 Assistant Professor, GSMSE, KAIST

  • 2016-Present Associate Professor, GSMSE, KAIST

  • 2011-Present Adjunct Professor, KI for Biocentury, KAIST

  • 2014-Present Adjunct Professor, Department of Biological Science, KAIST

  • 2018-Present Chief Investigator, Center for biomolecular & Cellular Structure (Protein Communication Group), IBS

Major Publications

  • Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell, 2007 Sep 7; 130(5):906-17.

  • Reconfiguration of the proteasome during chaperone-mediated assembly. Nature, 2013 May 23; 497(7450):512-6.

  • Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion. Nature Communications. 2014 Nov 14;5:5423.

  • Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14 and TLR4-MD2 for efficient LPS recognition and transfer. Immunity. 2017 Jan 17;46(1):38-50.

  • Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex. Neuron. 2017 Jun 21; 94(6): 1121-1131, Issue Highlights.

  • Multi-paratopic VEGF decoy receptor have superior anti-tumor effects through anti-EGFRs and targeted anti-angiogenic activities. Biomaterials. 2018 Apr 16;171:34-45.

  • Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2909-2913.


Honors and Awards

  • Young Scientist Award, Ministry of Science and Technology, Republic of Korea, 2007.

  • Agarwal Award, BMRC, KAIST, Republic of Korea, 2009.

  • Ewon Assistant Professor, KAIST, Republic of Korea, 2015.

  • Award for Academic Excellence, KAIST, Republic of Korea, 2017.

  • KAIST Top 10 Representative Researches Award, KAIST, 2017.

  • Asan Award in Medicine for Young Medical Scientists, Asan Foundation, 2018.

  • National R&D Excellence 100, Minister of Science and ICT, Republic of Korea, 2018.


Research Interests

  • Structure of Disease related-protein complex & Leucine-Rich Repeat (LRR) containing Protein

  • Structure-based Protein Engineering

  • Cryo-EM, X-ray Crystallography


Contacts

  • E-mail : kimhm@ibs.re.kr

  • Tel : +82-42-878-9400

  • Address : C264, 55 EXPO-ro, Doryong-dong, Yuseong-gu, Daejeon, 34126, Korea