Chief Investigator
Ho Min Kim, Ph.D.
Dr. Ho Min Kim joined the Graduate School of Medical science & Engineering (GSMSE), KAIST in 2011 and established the “Disease Molecule Biochemistry Lab”. Using structural biology techniques (X-ray Crystallography and Cryo-EM) as well as biochemical and cell-biological approaches, he has been investigated the molecular mechanisms of various protein complexes which play a critical role in human pathophysiology such as immune response and synaptogenesis. In parallel, based on the structure of disease-related protein complexes, he designed new therapeutic hybrid proteins and further develop them as potential biologics for cancer treatment.
In December, 2018, he has appointed as a chief investigator and launched the Protein Communication group (Center for biomolecular and cellular structure) at IBS Headquarter.
Educations
1995-1999 B.S., KAIST, Department of Biological Science
1999-2001 M.S., KAIST, Department of Biological Science
2001-2005 Ph.D., KAIST, Department of Biological Science
Research and Professional Careers
2005-2006 Postdoctoral Fellow (Prof. Ook Joon, Yoo) Biomedical Research Center, KAIST
2006-2007 Postdoctoral Fellow (Prof. Jie-oh, Lee), Department of Chemistry, KAIST
2007-2011 Postdoctoral Fellow (Prof. Yifan, Cheng), Department of Biophysics and Biochemistry, University of California San Francisco
2011-2015 Assistant Professor, GSMSE, KAIST
2016-Present Associate Professor, GSMSE, KAIST
2023-Present Professor, GSMSE, KAIST
2011-Present Adjunct Professor, KI for Biocentury, KAIST
2014-Present Adjunct Professor, Department of Biological Science, KAIST
2018-Present Chief Investigator, Center for biomolecular & Cellular Structure (Protein Communication Group), IBS
Major Publications
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell, 2007 Sep 7; 130(5):906-17.
Reconfiguration of the proteasome during chaperone-mediated assembly. Nature, 2013 May 23; 497(7450):512-6.
Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion. Nature Communications. 2014 Nov 14;5:5423.
Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14 and TLR4-MD2 for efficient LPS recognition and transfer. Immunity. 2017 Jan 17;46(1):38-50.
Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex. Neuron. 2017 Jun 21; 94(6): 1121-1131, Issue Highlights.
Multi-paratopic VEGF decoy receptor have superior anti-tumor effects through anti-EGFRs and targeted anti-angiogenic activities. Biomaterials. 2018 Apr 16;171:34-45.
Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2909-2913.
Honors and Awards
Young Scientist Award, Ministry of Science and Technology, Republic of Korea, 2007.
Agarwal Award, BMRC, KAIST, Republic of Korea, 2009.
Ewon Assistant Professor, KAIST, Republic of Korea, 2015.
Award for Academic Excellence, KAIST, Republic of Korea, 2017.
KAIST Top 10 Representative Researches Award, KAIST, 2017.
Asan Award in Medicine for Young Medical Scientists, Asan Foundation, 2018.
National R&D Excellence 100, Minister of Science and ICT, Republic of Korea, 2018.
Research Interests
Structure of Disease related-protein complex & Leucine-Rich Repeat (LRR) containing Protein
Structure-based Protein Engineering
Cryo-EM, X-ray Crystallography
Contacts
E-mail : kimhm@ibs.re.kr / hm_kim@kaist.ac.kr
Tel : +82-42-878-9400
Address : C264, 55 EXPO-ro, Doryong-dong, Yuseong-gu, Daejeon, 34126, Korea